Great Panther Silver has reported that about 60 people illegally occupied its Guanajuato mine complex in Mexico, on 9 March.
The Canadian silver mining and exploration firm said it has shut down mining, plant and administration services until the situation is resolved.
Great Panther said all employees and contractors are safe and accounted for, and that there have been no reports of violence.
The latest disruptions follow the violent incidents that recently occurred in and around the Guanajuato mine.
Great Panther Silver president and CEO Robert Archer said it appears that a few members of the mining co-operative who sold the mine to the company in 2005 when it was facing bankruptcy are behind the illegal occupation of its facilities.
"It is unknown at this time whether these members of the co-operative have been involved with recent activities of illegal miners," Archer said.
"We will work with municipal, state and federal authorities to find a peaceful and expedient resolution to this situation, however, we are currently reviewing all options to regain custody of our facility and ensure the security of our operations and our people."
In addition to Guanajuato mine complex, Great Panther also owns Topia operating mine in Mexico.
Great Panther said it is in the process of developing its San Ignacio project with a view to reaching production this year, and has two exploration projects, El Horcon and Santa Rosa.
The company is also pursuing mining opportunities within Latin America.